“Grey’s Anatomy” lead star Ellen Pompeo talked about Patrick Dempsey and how the show is doing without the actor. Pompeo on “The Ellen DeGeneres Show” told Ellen DeGeneres that “Everybody thought because Patrick [Dempsey] was leaving that it wouldn’t do well, but it’s doing very well.”

“Yeah, it’s amazing how much you get done without a penis,” she quipped.

The 46-year-old actress portrays Dr Meredith Grey on the series while Dempsey played the role of a neurosurgeon and Pompeo’s on-screen husband Dr Derek Shepherd. He died in the series last year after sustaining severe injuries following a car crash. ABC and “Grey’s Anatomy” creator Shonda Rhimes were slammed over Derek’s death.

Pompeo also admitted that Dempsey is missed in the set, Entertainment Tonight wrote.

“For me too, it’s how do I act without him? It’s more challenging for me. I’m more invested. I have to work harder to find my groove without that missing part. So it keeps me more engaged,” the actress admitted to DeGeneres.

Dempsey, who is also known as “McDreamy” on the show, earlier said his reasons for leaving the medical drama series were simply to try something new and different.

Pompeo also has her view why people continue to follow the ABC medical drama after 12 seasons, ABC News wrote.

“I think a lot of people were really upset about his departure, which is super understandable, but I think the change is part of the reason why the show goes on so long. I think people tune in to see what does the show look like now? What is Meredith going to do without Derek? I think they get so upset about the change, but change is precisely what everyone always needs to sort of get to the next place,” she said.

Pompeo also slammed reports that season 12 will be the last for the show.  “No, it’s not the last season,” she said.

“”Grey’s Anatomy” airs Thursdays at 8 p.m. ET on ABC.